The relationship between inflammatory markers and voxel-based gray matter volumes in nondemented older adults

H Zhang; PS Sachdev; W Wen; JD Crawford; H Brodaty; BT Baune; NA Kochan; MJ Slavin; S Reppermund; K Kang; JN Trollor

Journal article

The relationship between inflammatory markers and voxel-based gray matter volumes in nondemented older adults

H Zhang, PS Sachdev, W Wen, JD Crawford, H Brodaty, BT Baune, NA Kochan, MJ Slavin, S Reppermund, K Kang, JN Trollor

Neurobiology of Aging | ELSEVIER SCIENCE INC | Published : 2016

DOI: 10.1016/j.neurobiolaging.2015.10.008

Abstract

Ageing is characterized by chronically elevated inflammatory markers (IMs). Peripheral IM levels have been found in negative correlations with brain structural measures including global and lobar volumes and the hippocampus. This study investigated the relationship between 10 peripheral IMs and voxel-based gray matter (GM) volumes in nondemented older adults (n = 463). Two proinflammatory cytokines (tumor necrosis factor-α [TNF-α] and interleukin-1β) and 2 vascular IMs (vascular cellular adhesion molecule–1 and plasminogen activator inhibitor–1) were negatively correlated with regional GM volumes. TNF-α and interleukin-1β were both significantly correlated with GM volumes in the left occipit..

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University of Melbourne Researchers

Bernhard Baune Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

The present study was supported by the National Health and Medical Research Council of Australia Program Grant (ID 350833) and Project Grant (ID 510175), as well as an Australian Research Council Discovery Grant (ID DP0774213). The authors are grateful to all participants in the Sydney Memory and Ageing Study (MAS) and the MAS Research Team.